Association of Genetic Marker HLA-B27 with Spondyloarthritis In A Tertiary Care Centre In South India

Human leukocyte antigens (HLA) are gene products found in the major histocompatibility complex, aiding differentiation of “self” from “non-self” antigens, and is crucial for communication between immune cells human body. HLA-B27, specific, has a strong interrelation with different types Spondyloarthritis (SpA). The aim this study to frequency HLA-B27 suspected patients presenting axial peripheral joint involvement, who attended our tertiary care centre August-2017 January-2021. Patients fulfilling Assessment International Society (ASAS) criteria were included study, further classified into sub-groups. Blood samples collected CRP ESR tests along detection by RT-PCR method. Magnetic resonance imaging was done sacroiliac joints lower back pain. Analysis 289 SpA revealed 156 (54%) be positive 133 (46%) negative. There 98 (63%) Ankylosing spondylitis, 33 (21%) had Reactive arthritis, 19 (12%) Psoriatic 6 (4%) Undifferentiated Spondyloarthritis, inflammatory bowel disease diagnosed 0% patients. among (SpA) 54% (156), more common clinical manifestation men belonging age group 16-25 years spondylitis (AS) most sub-groups observed